Wyeth (WYE) is unexpectedly facing generic competition for its top drugs, most notably its blockbuster heartburn treatment Protonix. Generic Protonix is expected to contribute to flat sales and a possible earnings decline for Wyeth in 2008. Wyeth plans to reduce its work force by 4% to 6% by mid-year to cut costs.

Approved by the U.S. Food and Drug Administration in 2000, Protonix costs about $4.50 per tablet, Wyeth said. Generic Protonix is listed on drugstore.com at about $3.60 per pill.
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